Fri Jun 21 2024

109 articles - From Friday Jun 14 2024 to Friday Jun 21 2024

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Hepatology

Letter to The Editor: A multi-society Delphi consensus statement on new fatty liver disease nomenclature.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Systematic review: Patient-related, microbial, surgical, and histopathological risk factors for endoscopic post-operative recurrence in patients with Crohn's disease.

Risk factors for ePOR in international guidelines are not consistently reported as risk factors in current literature except for active smoking and prior bowel resection. To develop evidence-based, personalised strategies, large prospective studies are warranted to identify risk factors for ePOR. Validation studies of promising (bio)markers are also required.

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Clin Gastroenterol Hepatol

Perianal fistulizing Crohn's disease-associated anorectal and fistula cancers: systematic review and expert consensus.

Inflammatory bowel disease (IBD) clinicians should be aware of the risk of PFCD-associated anorectal and fistula cancers in al patients with PFCD. The TOpClass consortium consensus statements outlined herein offer guidance in managing this challenging scenario.

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STOPPING NUCLEOS(T)IDE ANALOGUES IN CHRONIC HEPATITIS B USING HBSAG THRESHOLDS: A META-ANALYSIS AND META-REGRESSION.

While EOTqHBsAg thresholds, ethnicity and followup duration strongly predict HBsAg loss, this is not true for VR and BR, hence stopping NA therapy should be considered cautiously.

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Sphingosine 1-Phosphate Receptor Modulators are Effective in Patients With Moderately to Severely Active Ulcerative Colitis and a Prior Biologic Exposure: A Meta-Analysis of Randomized Controlled Trials.

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Endosc Int Open

Endoscopic scoring indices for assessing disease severity in familial adenomatous polyposis: Systematic review.

There are no fully validated endoscopic disease severity indices for FAP. Development and validation of a reliable and responsive endoscopic disease severity instrument will be informative for clinical care and RCTs of pharmacological therapies for FAP.

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Gastrointest Endosc

Comparison of Endoscopic Mucosal Resection versus Endoscopic Submucosal Dissection for Barrett's Neoplasia and Esophageal Adenocarcinoma: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis demonstrates that ESD achieves higher en bloc, R0 and curative resection rates, with a tendency toward lower recurrence rates. These results suggest that ESD may be a more effective option for managing Barrett's neoplasia and EAC.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Characterisation of an outbreak of acute liver injury after ingestion of plant-based food supplement.

Natural food products are increasingly ubiquitous and may unexpectedly cause significant illness. All clinicians should inquire whether patients are consuming natural food products or herbal supplements and consider them as a potential cause of liver injury.

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Am J Gastroenterol

Opioids and the Gastrointestinal Tract: The Role of Peripherally Active µ-Opioid Receptor Antagonists in Modulating Intestinal Permeability.

In this review we briefly describe the physiology of the gastrointestinal epithelial border and discuss the impact of opioids on gastrointestinal function. Finally, we consider the use of peripherally active µ-opioid receptor antagonists to treat disrupted intestinal permeability resulting from opioid use and discuss the potential for improved morbidity and mortality in patients treated with methylnaltrexone for opioid-induced bowel disorders.

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SELF-REPORTED NON-CELIAC GLUTEN SENSITIVITY IN ITALIAN YOUNG ADULTS: A CROSS-SECTIONAL STUDY. A DIETARY FAD?

The high prevalence of people reporting symptoms after gluten ingestion requires that the diagnosis of NCGS should be ascertained with a double-blind controlled study to limit the number of people who improperly approach a gluten-free diet.

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The Burden of Overweight and Obesity-Associated Gastrointestinal Cancers in Low and Lower-Middle-Income Countries: A Global Burden of Disease 2019 Analysis.

The GI cancer-related burden from high BMI increased in LICs and lower MICs, necessitating a concerted effort to tackle the obesity pandemic.

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The Natural History after Ileal Pouch-Anal Anastomosis for Ulcerative Colitis: A Population-Based Cohort Study from the United States.

The incidence of inflammatory conditions of the pouch remains high in the current era, with 14% of patients requiring advanced therapies after IPAA.

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Clin Gastroenterol Hepatol

Novel Irritable Bowel Syndrome Subgroups are Reproducible in the Global Adult Population.

Even in the community, our original clusters derived from patients with physician-confirmed IBS identified groups of individuals with significantly higher rates of healthcare-seeking and abdominal surgery, more severe symptoms, and impairments in quality of life.

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Real-world effectiveness of fecal microbiota transplantation for first or second Clostridioides difficile infection.

Repeated FMT treatments demonstrate high effectiveness in managing patients with first or second CDI. Forwarding FMT in CDI treatment guidelines could improve patient survival.

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Role of Sex, Anxiety, and Resilience in the Association between Adverse Childhood Experiences and Irritable Bowel Syndrome.

Both men and women with a history of ACE are twice as likely to have IBS than those without an ACE. Anxiety mediated the relationship between ACE and IBS in men and women and resilience mediated this relationship only in women.

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The Revised Kyoto Criteria and Risk of Malignancy Among Patients With Intraductal Papillary Mucinous Neoplasms.

The revised Kyoto criteria stratify IPMN patients well in terms of the short- and long-term risks of pancreatic carcinoma diagnosis, potentially informing personalized patient management.

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The Role of Pancreatitis Risk Genes in Endocrine Insufficiency Development After Acute Pancreatitis in Children.

In this cohort of children with AP, pancreatitis risk genes and AP disease severity were associated with pre-DM or DM development post AP.

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Endosc Int Open

Computed tomography-based prediction of pancreatitis following biliary metal stent placement with the convolutional neural network.

The CNN-based model may increase predictability for pancreatitis following endoscopic placement of a biliary SEMS. Our findings support the potential of deep learning technology to improve prognostic models in pancreatobiliary therapeutic endoscopy.

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Novel physiological analysis using blood flow velocity for colonic polyps: Pilot study.

We found that mean microvascular blood flow velocity was significantly lower in ADs than in HPs and the surrounding non-neoplastic mucosa. These findings indicate that a novel dynamic approach with microvascular blood flow velocity using magnifying endoscopy may be useful in assessing physiological differences between ADs and HPs.

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Gastrointest Endosc

A multicenter, retrospective study of a through-the-needle injection-capable electrosurgical knife for endoscopic submucosal dissection.

A newly developed through-the-needle injection-capable ESD knife showed a good success rate and excellent safety at US centers. (ClinicalTrials.gov number, NCT04580940).

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Virtual indigo carmine chromoendoscopy images: A novel modality for peroral cholangioscopy using artificial intelligence technology (with video).

VICI in POCS proved valuable for visualizing surface structures and lesion margins and contributed to higher diagnostic accuracy comparable to NBI. In addition to NBI, VICI may be a novel supportive modality for POCS.

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Gut

Clinical consequences of computer-aided colorectal polyp detection.

Even if CADe appears to be slightly more sensitive than human endoscopists, the additional gain in ADR was minimal and follow-up intervals rarely changed. Additional inspection of non-neoplastic lesions was increased, adding to the inspection and/or polypectomy workload.

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High accuracy model for HBsAg loss based on longitudinal trajectories of serum qHBsAg throughout long-term antiviral therapy.

The novel GOLDEN model, based on longitudinal qHBsAg data, accurately predicts HBsAg clearance, provides reliable estimates of functional hepatitis B virus (HBV) cure and may have the potential to stratify different subsets of patients for novel anti-HBV therapies.

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Hepatology

Bintrafusp alfa and chemotherapy as first-line treatment in biliary tract cancer: A randomized phase ⅔ trial.

BA+GemCis did not provide a clinically meaningful benefit compared to GemCis alone as first-line treatment for BTC and the study was discontinued early (terminated August 20, 2021).

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Comprehensive profiling of lipid metabolic reprogramming expands precision medicine for hepatocellular carcinoma.

In conclusion, our study elucidates the metabolic reprogramming gnature of lipid metabolism in HCC, identifies prognostic markers, and therapeutic targets, and highlights potential metabolism-related targets for therapeutic intervention in HCC.

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Genetic predisposition to porto-sinusoidal vascular disorder.

When analysing the cell types in which these genes are expressed, we found that these genes are predominantly expressed in immune cells, suggesting that these cells may play a more important role in the development of porto-sinusoidal vascular disorder than previously thought. In addition, pathway analyses suggested that there may be 2 types of porto-sinusoidal vascular disorder associated with gene mutations: those resulting directly from morphogenetic abnormalities and those secondary to immune changes.

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HES V2.0 outperforms GALAD for detection of HCC: A phase 3 biomarker study in the United States.

In a prospective cohort study, HES V2.0 had a significantly higher performance for identifying new HCC, including early stage, than GALAD or ASAP.

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Liver transplantation for Alcohol-associated liver disease.

In this review, we summarize the current evidence on LT for ALD, from alcohol-associated hepatitis (AAH) to decompensated alcohol-associated cirrhosis. We discuss the indications, criteria, outcomes, and controversies of LT for these conditions, and highlight the knowledge gaps and research priorities in this field.

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Modulation of monocyte activity by hepatocellular MicroRNA delivery via hepatitis B virus surface antigen particles: Implications for pathobiology of chronic hepatitis B.

HBsAg particles carry hepatocellular miRNAs, including miR-939, which enter monocytes and alter their functional status such as IL-8 secretion. Our findings demonstrate that HBsAg-miR-939-IL-8 axis may play a crucial role in HBV-induced hepatic necro-inflammation and progression of advanced liver diseases.

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Spatial proteomic landscape of primary and relapsed hepatocellular carcinoma reveals immune escape characteristics in early relapse.

We comprehensively depicted the spatial landscape of single-cell dynamics and multicellular architecture within primary and relapsed HCC. Our findings highlight spatial organization is a prominent determinant of HCC recurrence and provide a valuable insight into the immune evasion mechanisms driving recurrence.

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Utility of methylated DNA markers for the diagnosis of malignant biliary strictures.

The selected methylated DNA markers demonstrated improved performance characteristics for the detection of MBS compared to cytology and FISH. ​ Therefore, MDMs should be considered viable candidates for inclusion in diagnostic testing algorithms.​.

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J Hepatol

Diagnostic Performance of Noninvasive Tests in Patients with MetALD in a Health Check-up Cohort.

The newly defined MetALD exhibited a high FIB-4 performance, demonstrating reasonable sensitivity and negative predictive value for the initial screening of advanced hepatic fibrosis in MetALD. Impact and implications In this cross-sectional study, data from 7,918 participants who underwent MRE were analyzed to assess the performance of fibrosis-4 (FIB-4) and nonalcoholic fatty liver disease fibrosis scores in metabolic dysfunction-associated steatotic liver disease (MASLD) and MASLD with increased alcohol intake (MetALD). We found that the newly identified MetALD group had high diagnostic accuracy with FIB-4, similar to the MASLD population. These results highlight the potential of FIB-4 as a reliable screening tool for MetALD, even when specific subgroups are considered. Therefore, FIB-4 is a valuable screening tool for identifying advanced fibrosis in the MetALD population.

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Epigenetic scars in regulatory T cells are retained after successful treatment of chronic hepatitis C with direct-acting antivirals.

Here we longitudinally examined phenotypic, transcriptomic, and epigenetic alterations in peripheral blood regulatory T (T cells are maintained at phenotypic, transcriptomic, and epigenetic levels even after successful DAA treatment. Further in-depth studies are required to investigate the long-term clinical outcomes of patients who have recovered from chronic HCV infection.

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Primary cilia as a targetable node between biliary injury, senescence and regeneration in liver transplantation.

Primary cilia play an essential role in biliary regeneration and we demonstrate that senolytics and cilia-stabilising treatments provide a potential therapeutic opportunity to reduce the rate of biliary complications and improve clinical outcomes in liver transplantation. Impact and implications Up to 25% of liver transplants result in biliary complications, leading to additional surgery, retransplants, or death. We found that the incidence of biliary complications is increased by damage to the primary cilium, an antenna that protrudes from the cell and is key to regeneration. Here, we show that treatments that preserve the primary cilia during the transplant process provide a potential solution to reduce the rates of biliary complications.

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Sodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide.

NTCP genetic polymorphisms were identified by Sanger sequencing. Results Of the 6 NTCP polymorphisms studied in 209 CHD untreated patients, carriers of rs17556915 TT/CC (N=142) compared to CT (N=67) genotype presented higher median HDV RNA levels (5.39 vs 4.75 log T genetic polymorphisms may influence baseline HDV RNA load both in untreated and BLV treated patients with CHD and may contribute to identify patients with different early virological responses to BLV.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Retreatment of direct-acting antiviral failures with the current first-line regimens for patients with chronic hepatitis C.

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Editorial: Surgery to reduce opioid use in Crohn's disease: Does a classic solution address a newer problem?

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Clin Gastroenterol Hepatol

Blue Notes.

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Editorial: Ustekinumab and Vedolizumab Safety and Clearance in Pregnancy with Inflammatory Bowel Disease: Stop the Disease, not the Drug!

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Endosc Int Open

Retention of endoscopic capsules in diverticula: Literature review of a capsule endoscopy rarity.

The most common type is Meckel's diverticulum, and endoscopy is the primary management. Capsule endoscopy retentions are extremely rare, with only 34 cases reported since the technology's introduction.

Pubmed   Journal   ReadQx   PMC

Gastroenterology

Gastrointestinal biofilms - Endoscopic detection, disease relevance and therapeutic strategies.

Critical knowledge gaps and open research questions regarding the biofilm's exact pathophysiological relevance and key hurdles in translating therapeutic advances into the clinic are discussed. Taken together, this review summarises the status quo in gut biofilm research and provides perspectives and guidance for future research and therapeutic strategies.

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Presentation of the AGA William Beaumont Prize in Gastroenterology to Hashem B. El-Serag, MD, MPH.

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Gastrointest Endosc

A new kid on the "bloc"? A case for another submucosal injection agent for endoscopic resection of early gastric neoplasms.

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Serology-assisted endoscopic screening for gastric cancer.

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Gut

Stomach microbiota in gastric cancer development and clinical implications.

Potential translational and clinical implications of using gastric microbes for GC diagnosis, prognosis and therapeutics are also evaluated, with further discussion on conceptual haziness and limitations at present. Finally, we highlight that modulating microbes is a novel and promising frontier for the prevention and management of GC, which necessitates future in-depth investigations.

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J Hepatol

Integration of new technologies in the multidisciplinary approach to primary liver tumours: The next-generation tumour board.

Navigating this evolution also requires a focus on enhancing basic, translational, and clinical research, as well as boosting clinical trials through an upgraded use of MDTBs as hubs for scientific collaboration and raising literacy about AI and new technologies. In this review, we will delineate the current unmet needs in the clinical management of primary liver cancers, discuss our perspective on the future role of MDTBs in primary liver cancers ("next generation" MDTBs), and unravel the potential power and limitations of novel technologies that may shape the multidisciplinary care landscape for primary liver cancers in the coming decade.

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Liver Biopsy Evaluation in MASH Drug Development: Think Thrice, Act Wise.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Concerns Regarding Bleeding Risk of Cold vs Hot Snare Polypectomy for Small Pedunculated Colorectal Polyps.

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Response to Biswas et al.

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Response to Thabut et al.

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Clin Gastroenterol Hepatol

Fishbone penetration causing liver abscess: a case report.

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Plummer-Vinson Syndrome: Classic triad of iron deficiency anemia, dysphagia, and esophageal webs.

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Revisiting meta-analyses of placebo response in drug trials for irritable bowel syndrome: A call to disclose excipients.

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Sequential SAFE Score and Transient Elastography in Detecting of Significant Fibrosis in Asian Patients with MASLD.

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Endosc Int Open

Cholangioscopy-assisted electrocoagulation therapy with electroacupuncture device for intraductal superficial lesions or hemobilia in porcine model.

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EUS-guided gallbladder drainage using a bicolored double-pigtail plastic stent facilitates appropriate stent positioning.

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The "Dumpling method:" Novel technique for preventing PuraStat migration and enhancing hemostasis.

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Endoscopy

Artificial intelligence (AI) systems for detection of Barrett's neoplasia: time to bridge domain gaps and explore human-AI interaction.

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Capsule endoscopy emissions: less than expected and largely influenced by patient transport.

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Cholangioscopy-assisted extraction of choledocholithiasis through novel papillary support: the protective effect on the sphincter of Oddi.

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Efficacy of underwater endoscopic intermuscular dissection in the management of a rectal neuroendocrine tumor.

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Nonexposed endoscopic wall inversion surgery with sentinel node mapping for a high risk gastric lesion.

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Peroral endoscopic myotomy using a novel thin therapeutic scope.

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Tightening the purse strings: a stent-free path to a lasting endoscopic gastroenterostomy.

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Gastroenterology

Holistic Candidate Review.

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Gastrointest Endosc

A bougie makes peroral endoscopic myotomies easier in sigmoid-type achalasia.

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Application of iodine staining in endoscopic ligation for internal hemorrhoids:Where exactly is the anorectal line?

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Esophageal Obstruction After Bleeding Within an Esophageal Duplication Cyst.

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Heterotopic Pancreatic Tissue Containing a Mucinous Cystic Neoplasm Within the Duodenum With Fish-Mouth Appearance on Endoscopy.

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Natural Orifice Transluminal Endoscopic Surgery for Partial Cholecystectomy: First Clinical Practice.

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Top Tips for Endoscopic Ultrasound Guided Celiac Plexus Block and Neurolysis.

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Gut

Blautia: a key moderator of compulsivity towards chocolate?

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Diagnostic upper GI endoscopy: can less mean more?

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Poking at probiotic mechanisms and microbial implications in cancer prevention and treatment.

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Presenilins: the hidden guardians of gut health in Alzheimer's disease.

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Hepatology

Exploring the role of macrophages in the pathogenesis of Alcohol-associated liver disease.

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Hepatology Highlights.

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Is digital pathology the new standard in MASH trials?

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Letter to the Editor: Clinical outcomes and prognostic factors after HCV clearance with DAA in HIV/HCV-coinfected patients with advanced fibrosis/cirrhosis.

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Letter to the Editor: MAFLD versus MASLD criteria debate- Certainly not for children!

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Letter to the Editor: Multifactorial steatotic liver disease: A new entity to be included in new international classification of liver steatosis.

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Letter to the Editor: The WHO HDV RNA international standard does not reflect variability of real-world samples.

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Process Measures to Improve Outcomes During Peri-Procedure Management of Coagulopathy in Cirrhosis.

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The exact predictive value of HBcrAg and HBV RNA in serological status and disease activity in CHB.

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J Hepatol

Estrogen receptor alpha in the female liver: Dr. Jekyll and Mr. Hyde.

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The liver in haematologic oncologic disorders.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Redefining liver health-Personalised approach to assessment of serum ALT in clinical practice. Authors' reply.

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Letter: Retargeting the lens-From general ChatGPT to specialised medical LLMs.

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Letter: Shifting focus-From ChatGPT to specialised medical LLMs: Authors' reply.

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Clin Gastroenterol Hepatol

Not so nutty for coconut water.

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Personalizing Aspirin Therapy in Gastrointestinal Cancer: The Critical Role of Age Stratification.

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Screening endoscopy in patients with advanced chronic liver disease - is it all about varices?

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Screening for Social Determinants of Health in Underserved Populations to Promote Better Outcomes in ALD and MASLD.

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Endosc Int Open

Comment on "Using a customized GPT to provide guideline-based recommendations for management of pancreatic cystic lesions".

Pubmed   Journal   ReadQx   PMC

Gastroenterology

All Fibers Are Not Created Equal.

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Implications and Future Directions for Octreotide Use in Angiodysplasia Management.

Pubmed   Journal   ReadQx 

Protease inhibitor for chronic pancreatitis: Where do we go next?

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Are endosonographic shear wave measurement results reliable without interquartile range median value?

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Prophylactic clipping for patients using oral antithrombotic agents: an individualized strategy is needed.

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Reassessing radiofrequency ablation in malignant biliary strictures: a closer look at a randomized controlled trial.

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Gut

Association between appendectomy and Parkinson's disease from the UK Biobank.

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Familial pancreatitis associated with a splice-site variant in CPA1.

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Long-term stability of the faecal microbiome profile in faecal immunochemical test (FIT) samples.

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J Hepatol

Does long-term use of tenofovir disoproxil fumarate affect fracture risk in patients with chronic hepatitis B?

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EVIDENCE-BASED FAILURE OF STAGE HIERARCHY THERAPEUTIC APPROACH TO HCC.

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Implications of Mycophenolate Mofetil in a reproductive age patient cohort: Maternal Fetal Medicine point of view.

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No need for complex blood purification systems for renal replacement therapy during long-term liver normothermic machine perfusion.

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Reply 'Exploring hepatocellular carcinoma risks in sub-Saharan African and Afro-Surinamese individuals with chronic hepatitis B living in Europe'.

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Reply: Mycophenolate Mofetil in Autoimmune Hepatitis: Are We Ready for Primetime?

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